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KMID : 0608520080140010107
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Korean Journal of Oriental Medicine
2008 Volume.14 No. 1 p.107 ~ p.111
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Quantitative analysis of Cynanchum wilfordii Hemsley
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Lee Hye-won
Park So-young
Lee A-eong
Chae Sung-wook
Choi Go-Ya
Choo Byung-kil
Kim Ho-kyoung
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Abstract
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Objectives : Cynanchum wilfordii(Asclepiadaceae) has been traditionally used as a tonic, the prevention and treatment of various geriatric diseases in Korea. Acetophenone derivatives from C. wilfordii showed neuroprotective activity. In this study, two acetophenones were isolated and quantitative determination of acetophenones from C. wilfordii has been developed for quality stand. Methods :Three acetophenone derivatives were isolated from methanol extract of C. wilfordii by the chromatographic separation. Their structures were identified as cynandione A, 2,5-dihydroxy acetophenone and cynanchone A on the basis of spectral data(MS, ¹H-NMR, ¹³C-NMR) and chemical analysis. HPLC analysis was performed to determine the contents of cynandione A and 2,5-dihydroxyacetophenone in C. wilfordii. Results: According to the results, the contents of cynandione A and 2,5- dihydroxyacetophenone were 0.274%, 0.035% by HPLC, respectively. Conclusions: In these results, we have determined the contents of cynandione A and 2.5-dihydroxyacetophenone in Cynanchum wilfordii, respectively. We hope that this study will contribute to the standardization and quality control of herbal medicine.
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KEYWORD
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Cynanchum wilfordii, asclepiadaceae, cynandione A, 2, 5-dihydroxy acetophenone, cynanchone A
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